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Characterization of Nicotinamidases: Steady-State Kinetic Parameters, Class-wide Inhibition by Nicotinaldehydes and Catalytic Mechanism

Nicotinamidases are metabolic enzymes that hydrolyze nicotinamide to nicotinic acid. These enzymes are widely distributed across biology, with examples found encoded in the genomes of Mycobacteria, Archaea, Eubacteria, Protozoa, yeast and invertebrates but there are none found in mammals. Although r...

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Autori principali: French, Jarrod B., Cen, Yana, Vrablik, Tracy L., Xu, Ping, Allen, Eleanor, Hanna-Rose, Wendy, Sauve, Anthony A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010197/
https://ncbi.nlm.nih.gov/pubmed/20979384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1012518
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