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Characterization of Nicotinamidases: Steady-State Kinetic Parameters, Class-wide Inhibition by Nicotinaldehydes and Catalytic Mechanism

Nicotinamidases are metabolic enzymes that hydrolyze nicotinamide to nicotinic acid. These enzymes are widely distributed across biology, with examples found encoded in the genomes of Mycobacteria, Archaea, Eubacteria, Protozoa, yeast and invertebrates but there are none found in mammals. Although r...

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Bibliographic Details
Main Authors: French, Jarrod B., Cen, Yana, Vrablik, Tracy L., Xu, Ping, Allen, Eleanor, Hanna-Rose, Wendy, Sauve, Anthony A.
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010197/
https://ncbi.nlm.nih.gov/pubmed/20979384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1012518
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