Modulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity and Genistein Binding by Cytosolic pH

Potentiators are molecules that increase the activity of the cystic fibrosis transmembrane conductance regulator (CFTR). Some potentiators can also inhibit CFTR at higher concentrations. The activating binding site is thought to be located at the interface of the dimer formed by the two nucleotide-b...

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Bibliographische Detailangaben
Hauptverfasser: Melani, Raffaella, Tomati, Valeria, Galietta, Luis J. V., Zegarra-Moran, Olga
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Membrane Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009886/
https://ncbi.nlm.nih.gov/pubmed/20974851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.166850
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