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Direct Sensing of Intracellular pH by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Cl(−) Channel

In cystic fibrosis (CF), dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(−) channel disrupts epithelial ion transport and perturbs the regulation of intracellular pH (pH(i)). CFTR modulates pH(i) through its role as an ion channel and by regulating transport proteins...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chen, Jeng-Haur, Cai, Zhiwei, Sheppard, David N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790979/
https://ncbi.nlm.nih.gov/pubmed/19837660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.072678
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