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Acute inhibition of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(−) channel by thyroid hormones involves multiple mechanisms

The chemical structures of the thyroid hormones triiodothyronine (T(3)) and thyroxine (T(4)) resemble those of small-molecules that inhibit the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(−) channel. We therefore tested the acute effects of T(3), T(4) and reverse T(3) (rT(3)) on re...

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Detalhes bibliográficos
Main Authors: Cai, Zhiwei, Li, Hongyu, Chen, Jeng-Haur, Sheppard, David N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798681/
https://ncbi.nlm.nih.gov/pubmed/23784545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00052.2013
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