Phosphatidylinositol 3-Kinase (PI3K) Signaling via Glycogen Synthase Kinase-3 (Gsk-3) Regulates DNA Methylation of Imprinted Loci

Glycogen synthase kinase-3 (Gsk-3) isoforms, Gsk-3α and Gsk-3β, are constitutively active, largely inhibitory kinases involved in signal transduction. Underscoring their biological significance, altered Gsk-3 activity has been implicated in diabetes, Alzheimer disease, schizophrenia, and bipolar dis...

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Main Authors: Popkie, Anthony P., Zeidner, Leigh C., Albrecht, Ashley M., D'Ippolito, Anthony, Eckardt, Sigrid, Newsom, David E., Groden, Joanna, Doble, Bradley W., Aronow, Bruce, McLaughlin, K. John, White, Peter, Phiel, Christopher J.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2010
נושאים:
Signal Transduction
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009859/
https://ncbi.nlm.nih.gov/pubmed/21047779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.170704
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