Phosphatidylinositol 3-Kinase (PI3K) Signaling via Glycogen Synthase Kinase-3 (Gsk-3) Regulates DNA Methylation of Imprinted Loci

Glycogen synthase kinase-3 (Gsk-3) isoforms, Gsk-3α and Gsk-3β, are constitutively active, largely inhibitory kinases involved in signal transduction. Underscoring their biological significance, altered Gsk-3 activity has been implicated in diabetes, Alzheimer disease, schizophrenia, and bipolar dis...

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Autors principals: Popkie, Anthony P., Zeidner, Leigh C., Albrecht, Ashley M., D'Ippolito, Anthony, Eckardt, Sigrid, Newsom, David E., Groden, Joanna, Doble, Bradley W., Aronow, Bruce, McLaughlin, K. John, White, Peter, Phiel, Christopher J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009859/
https://ncbi.nlm.nih.gov/pubmed/21047779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.170704
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