Gene Expression Profiling in Mouse Embryonic Stem Cells Reveals Glycogen Synthase Kinase-3-Dependent Targets of Phosphatidylinositol 3-Kinase and Wnt/β-Catenin Signaling Pathways

Glycogen synthase kinase-3 (Gsk-3) activity is an important regulator of numerous signal transduction pathways. Gsk-3 activity is the sum of two largely redundant proteins, Gsk-3α and Gsk-3β, and in general, Gsk-3 is a negative regulator of cellular signaling. Genetic deletion of both Gsk-3α and Gsk...

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Detalhes bibliográficos
Main Authors: Bartman, Colleen M., Egelston, Jennifer, Kattula, Sravya, Zeidner, Leigh C., D’Ippolito, Anthony, Doble, Bradley W., Phiel, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Endocrinology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4131280/
https://ncbi.nlm.nih.gov/pubmed/25165462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2014.00133
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