Niclosamide Prevents the Formation of Large Ubiquitin-Containing Aggregates Caused by Proteasome Inhibition

BACKGROUND: Protein aggregation is a hallmark of many neurodegenerative diseases and has been linked to the failure to degrade misfolded and damaged proteins. In the cell, aberrant proteins are degraded by the ubiquitin proteasome system that mainly targets short-lived proteins, or by the lysosomes...

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Main Authors: Gies, Esther, Wilde, Inga, Winget, Jason M., Brack, Maria, Rotblat, Barak, Novoa, Carolina Arias, Balgi, Aruna D., Sorensen, Poul H., Roberge, Michel, Mayor, Thibault
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009716/
https://ncbi.nlm.nih.gov/pubmed/21203451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014410
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