Niclosamide Prevents the Formation of Large Ubiquitin-Containing Aggregates Caused by Proteasome Inhibition

BACKGROUND: Protein aggregation is a hallmark of many neurodegenerative diseases and has been linked to the failure to degrade misfolded and damaged proteins. In the cell, aberrant proteins are degraded by the ubiquitin proteasome system that mainly targets short-lived proteins, or by the lysosomes...

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Hauptverfasser: Gies, Esther, Wilde, Inga, Winget, Jason M., Brack, Maria, Rotblat, Barak, Novoa, Carolina Arias, Balgi, Aruna D., Sorensen, Poul H., Roberge, Michel, Mayor, Thibault
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009716/
https://ncbi.nlm.nih.gov/pubmed/21203451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014410
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