XLF regulates filament architecture of the XRCC4·Ligase IV complex

DNA ligase IV (LigIV) is critical for non-homologous end-joining (NHEJ), the major DNA double-strand break (DSB) repair pathway in human cells, and LigIV activity is regulated by XRCC4 and XLF (XRCC4-like factor) interactions. Here, we employ X-ray scattering (SAXS) data to characterize three-dimens...

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Detalhes bibliográficos
Main Authors: Hammel, Michal, Yu, Yaping, Fang, Shujuan, Lees-Miller, Susan P., Tainer, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3008546/
https://ncbi.nlm.nih.gov/pubmed/21070942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2010.09.009
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