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Consequences of cisplatin binding on nucleosome structure and dynamics
The effects of cisplatin binding to DNA were explored at the nucleosome level to incorporate key features of the eukaryotic nuclear environment. An X-ray crystal structure of a site-specifically platinated nucleosome carrying a 1,3-cis-{Pt(NH(3))(2)}(2+)-d(GpTpG) intrastrand cross-link reveals the d...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3008157/ https://ncbi.nlm.nih.gov/pubmed/21168769 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.10.018 |
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