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Consequences of cisplatin binding on nucleosome structure and dynamics

The effects of cisplatin binding to DNA were explored at the nucleosome level to incorporate key features of the eukaryotic nuclear environment. An X-ray crystal structure of a site-specifically platinated nucleosome carrying a 1,3-cis-{Pt(NH(3))(2)}(2+)-d(GpTpG) intrastrand cross-link reveals the d...

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Bibliografiske detaljer
Main Authors: Todd, Ryan C., Lippard, Stephen J.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3008157/
https://ncbi.nlm.nih.gov/pubmed/21168769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.10.018
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