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Cisplatin Damage Overrides the Predefined Rotational Setting of Positioned Nucleosomes

Cisplatin and carboplatin are used successfully to treat various types of cancer. The drugs target the nucleosomes of cancer cells and form intrastrand DNA cross-links that are located in the major groove. We constructed two site-specifically modified nucleosomes containing defined intrastrand cis-{...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ober, Matthias, Lippard, Stephen J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2501106/
https://ncbi.nlm.nih.gov/pubmed/17432860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja0706145
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