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Cisplatin Damage Overrides the Predefined Rotational Setting of Positioned Nucleosomes
Cisplatin and carboplatin are used successfully to treat various types of cancer. The drugs target the nucleosomes of cancer cells and form intrastrand DNA cross-links that are located in the major groove. We constructed two site-specifically modified nucleosomes containing defined intrastrand cis-{...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2501106/ https://ncbi.nlm.nih.gov/pubmed/17432860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja0706145 |
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