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Platinum anticancer drug damage enforces a particular rotational setting of DNA in nucleosomes
We constructed two site-specifically modified nucleosomes containing an intrastrand cis-{Pt(NH(3))(2)}(2+) 1,3-d(GpTpG) cross-link, similar to one formed by the anticancer drugs carboplatin and cisplatin on DNA, and investigated their structures by hydroxyl radical footprinting and exonuclease III d...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1194956/ https://ncbi.nlm.nih.gov/pubmed/16116097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506025102 |
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