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A 1,2-d(GpG) Cisplatin Intrastrand Cross-link Influences the Rotational and Translational Setting of DNA in Nucleosomes
The mechanism of action of platinum-based anticancer drugs such as cis-diamminedichloro-platinum( II), or cisplatin, involves three sequential steps: cell entry, drug activation, and target binding. A major target in the cell, responsible for the anticancer activity, is nuclear DNA, which is package...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2739446/ https://ncbi.nlm.nih.gov/pubmed/18269283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja710220x |
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