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A 1,2-d(GpG) Cisplatin Intrastrand Cross-link Influences the Rotational and Translational Setting of DNA in Nucleosomes

The mechanism of action of platinum-based anticancer drugs such as cis-diamminedichloro-platinum( II), or cisplatin, involves three sequential steps: cell entry, drug activation, and target binding. A major target in the cell, responsible for the anticancer activity, is nuclear DNA, which is package...

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Библиографические подробности
Главные авторы: Ober, Matthias, Lippard, Stephen J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2739446/
https://ncbi.nlm.nih.gov/pubmed/18269283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja710220x
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