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Nuclease Digestion and Mass Spectrometric Characterization of Oligodeoxyribonucleotides Containing 1,2-GpG, 1,2-ApG, and 1,3-GpXpG Cisplatin Intrastrand Cross-links
BACKGROUND: The primary mode of action for cis-diamminedichloroplatinum (II), referred to as cisplatin, towards the treatment of solid malignancies is through formation of cross-links with DNA at purine sites, especially guanines. METHODS: We prepared oligodeoxyribonucleotides (ODNs) containing a 1,...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3625460/ https://ncbi.nlm.nih.gov/pubmed/23266768 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cca.2012.12.010 |
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