Caricamento...

Nuclease Digestion and Mass Spectrometric Characterization of Oligodeoxyribonucleotides Containing 1,2-GpG, 1,2-ApG, and 1,3-GpXpG Cisplatin Intrastrand Cross-links

BACKGROUND: The primary mode of action for cis-diamminedichloroplatinum (II), referred to as cisplatin, towards the treatment of solid malignancies is through formation of cross-links with DNA at purine sites, especially guanines. METHODS: We prepared oligodeoxyribonucleotides (ODNs) containing a 1,...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Williams, Renee T., Nalbandian, Jenifer, Tu, Audrey, Wang, Yinsheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625460/
https://ncbi.nlm.nih.gov/pubmed/23266768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cca.2012.12.010
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !