Nuclease Digestion and Mass Spectrometric Characterization of Oligodeoxyribonucleotides Containing 1,2-GpG, 1,2-ApG, and 1,3-GpXpG Cisplatin Intrastrand Cross-links

BACKGROUND: The primary mode of action for cis-diamminedichloroplatinum (II), referred to as cisplatin, towards the treatment of solid malignancies is through formation of cross-links with DNA at purine sites, especially guanines. METHODS: We prepared oligodeoxyribonucleotides (ODNs) containing a 1,...

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Hlavní autoři: Williams, Renee T., Nalbandian, Jenifer, Tu, Audrey, Wang, Yinsheng
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625460/
https://ncbi.nlm.nih.gov/pubmed/23266768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cca.2012.12.010
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