Debio 0507 primarily forms diaminocyclohexane-Pt-d(GpG) and -d(ApG) DNA adducts in HCT116 cells

PURPOSE: To characterize the cellular action mechanism of Debio 0507, we compared the major DNA adducts formed by Debio 0507- and oxaliplatin-treated HCT116 human colon carcinoma cells by a combination of inductively coupled plasma mass spectrometry (ICP-MS) and ultra-performance liquid chromatograp...

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Main Authors: King, C. L., Ramachandran, S., Chaney, S. G., Collins, L., Swenberg, J. A., deKrafft, K. E., Lin, W., Cicurel, L., Barbier, M.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3777240/
https://ncbi.nlm.nih.gov/pubmed/21968950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-011-1744-3
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