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Structure of duplex DNA containing the cisplatin 1,2-{Pt(NH)(3))(2)}(2+)-d(GpG) cross-link at 1.77 Å resolution
We report the 1.77-Å resolution X-ray crystal structure of a dodecamer DNA duplex with the sequence 5′-CCTCTGGTCTCC-3′ that has been modified to contain a single engineered 1,2-cis-{Pt(NH)(3))(2)}(2+)-d(GpG) cross-link, the major DNA adduct of cisplatin. These data represent a significant improvemen...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2917232/ https://ncbi.nlm.nih.gov/pubmed/20541266 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2010.04.005 |
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