Antiphospholipid antibodies promote leukocyte–endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2

In antiphospholipid syndrome (APS), antiphospholipid antibodies (aPL) binding to β2 glycoprotein I (β2GPI) induce endothelial cell–leukocyte adhesion and thrombus formation via unknown mechanisms. Here we show that in mice both of these processes are caused by the inhibition of eNOS. In studies of c...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Ramesh, Sangeetha, Morrell, Craig N., Tarango, Cristina, Thomas, Gail D., Yuhanna, Ivan S., Girardi, Guillermina, Herz, Joachim, Urbanus, Rolf T., de Groot, Philip G., Thorpe, Philip E., Salmon, Jane E., Shaul, Philip W., Mineo, Chieko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3007129/
https://ncbi.nlm.nih.gov/pubmed/21123944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39828
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados