Antiphospholipid antibodies promote leukocyte–endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2

In antiphospholipid syndrome (APS), antiphospholipid antibodies (aPL) binding to β2 glycoprotein I (β2GPI) induce endothelial cell–leukocyte adhesion and thrombus formation via unknown mechanisms. Here we show that in mice both of these processes are caused by the inhibition of eNOS. In studies of c...

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Hlavní autoři: Ramesh, Sangeetha, Morrell, Craig N., Tarango, Cristina, Thomas, Gail D., Yuhanna, Ivan S., Girardi, Guillermina, Herz, Joachim, Urbanus, Rolf T., de Groot, Philip G., Thorpe, Philip E., Salmon, Jane E., Shaul, Philip W., Mineo, Chieko
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3007129/
https://ncbi.nlm.nih.gov/pubmed/21123944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39828
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