Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium

In the antiphospholipid syndrome (APS), antiphospholipid antibody (aPL) recognition of β2 glycoprotein I promotes thrombosis, and preclinical studies indicate that this is due to endothelial nitric oxide synthase (eNOS) antagonism via apolipoprotein E receptor 2 (apoER2)-dependent processes. How apo...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Sacharidou, Anastasia, Chambliss, Ken L., Ulrich, Victoria, Salmon, Jane E., Shen, Yu-Min, Herz, Joachim, Hui, David Y., Terada, Lance S., Shaul, Philip W., Mineo, Chieko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Plenary Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5946764/
https://ncbi.nlm.nih.gov/pubmed/29500169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-11-814681
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