Antiphospholipid antibodies promote leukocyte–endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2

In antiphospholipid syndrome (APS), antiphospholipid antibodies (aPL) binding to β2 glycoprotein I (β2GPI) induce endothelial cell–leukocyte adhesion and thrombus formation via unknown mechanisms. Here we show that in mice both of these processes are caused by the inhibition of eNOS. In studies of c...

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Main Authors: Ramesh, Sangeetha, Morrell, Craig N., Tarango, Cristina, Thomas, Gail D., Yuhanna, Ivan S., Girardi, Guillermina, Herz, Joachim, Urbanus, Rolf T., de Groot, Philip G., Thorpe, Philip E., Salmon, Jane E., Shaul, Philip W., Mineo, Chieko
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2010
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3007129/
https://ncbi.nlm.nih.gov/pubmed/21123944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39828
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