Antiphospholipid antibodies promote leukocyte–endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2

In antiphospholipid syndrome (APS), antiphospholipid antibodies (aPL) binding to β2 glycoprotein I (β2GPI) induce endothelial cell–leukocyte adhesion and thrombus formation via unknown mechanisms. Here we show that in mice both of these processes are caused by the inhibition of eNOS. In studies of c...

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Bibliographic Details
Main Authors: Ramesh, Sangeetha, Morrell, Craig N., Tarango, Cristina, Thomas, Gail D., Yuhanna, Ivan S., Girardi, Guillermina, Herz, Joachim, Urbanus, Rolf T., de Groot, Philip G., Thorpe, Philip E., Salmon, Jane E., Shaul, Philip W., Mineo, Chieko
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2010
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3007129/
https://ncbi.nlm.nih.gov/pubmed/21123944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39828
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