Inhibitors of Foot and Mouth Disease Virus Targeting a Novel Pocket of the RNA-Dependent RNA Polymerase

BACKGROUND: Foot-and-Mouth Disease Virus (FMDV) is a picornavirus that infects cloven-hoofed animals and leads to severe losses in livestock production. In the case of an FMD outbreak, emergency vaccination requires at least 7 days to trigger an effective immune response. There are currently no appr...

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Main Authors: Durk, Ryan C., Singh, Kamalendra, Cornelison, Ceili A., Rai, Devendra K., Matzek, Kayla B., Leslie, Maxwell D., Schafer, Elizabeth, Marchand, Bruno, Adedeji, Adeyemi, Michailidis, Eleftherios, Dorst, Christopher A., Moran, Jennifer, Pautler, Christie, Rodriguez, Luis L., McIntosh, Mark A., Rieder, Elizabeth, Sarafianos, Stefan G.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3006429/
https://ncbi.nlm.nih.gov/pubmed/21203539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015049
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