Biochemical Mechanism of HIV-1 Resistance to Rilpivirine

Rilpivirine (RPV) is a second generation nonnucleoside reverse transcriptase (RT) inhibitor (NNRTI) that efficiently inhibits HIV-1 resistant to first generation NNRTIs. Virological failure during therapy with RPV and emtricitabine is associated with the appearance of E138K and M184I mutations in RT...

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Detalhes bibliográficos
Main Authors: Singh, Kamalendra, Marchand, Bruno, Rai, Devendra K., Sharma, Bechan, Michailidis, Eleftherios, Ryan, Emily M., Matzek, Kayla B., Leslie, Maxwell D., Hagedorn, Ariel N., Li, Zhe, Norden, Pieter R., Hachiya, Atsuko, Parniak, Michael A., Xu, Hong-Tao, Wainberg, Mark A., Sarafianos, Stefan G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488081/
https://ncbi.nlm.nih.gov/pubmed/22955279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.398180
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