Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase

We report key mechanistic differences between the reverse transcriptases (RT) of human immunodeficiency virus type-1 (HIV-1) and of xenotropic murine leukemia virus-related virus (XMRV), a gammaretrovirus that can infect human cells. Steady and pre-steady state kinetics demonstrated that XMRV RT is...

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Autors principals: Ndongwe, Tanyaradzwa P., Adedeji, Adeyemi O., Michailidis, Eleftherios, Ong, Yee Tsuey, Hachiya, Atsuko, Marchand, Bruno, Ryan, Emily M., Rai, Devendra K., Kirby, Karen A., Whatley, Angela S., Burke, Donald H., Johnson, Marc, Ding, Shilei, Zheng, Yi-Min, Liu, Shan-Lu, Kodama, Ei-Ichi, Delviks-Frankenberry, Krista A., Pathak, Vinay K., Mitsuya, Hiroaki, Parniak, Michael A., Singh, Kamalendra, Sarafianos, Stefan G.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2012
Matèries:
Nucleic Acid Enzymes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245923/
https://ncbi.nlm.nih.gov/pubmed/21908397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr694
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