Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase

We report key mechanistic differences between the reverse transcriptases (RT) of human immunodeficiency virus type-1 (HIV-1) and of xenotropic murine leukemia virus-related virus (XMRV), a gammaretrovirus that can infect human cells. Steady and pre-steady state kinetics demonstrated that XMRV RT is...

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מידע ביבליוגרפי
Main Authors: Ndongwe, Tanyaradzwa P., Adedeji, Adeyemi O., Michailidis, Eleftherios, Ong, Yee Tsuey, Hachiya, Atsuko, Marchand, Bruno, Ryan, Emily M., Rai, Devendra K., Kirby, Karen A., Whatley, Angela S., Burke, Donald H., Johnson, Marc, Ding, Shilei, Zheng, Yi-Min, Liu, Shan-Lu, Kodama, Ei-Ichi, Delviks-Frankenberry, Krista A., Pathak, Vinay K., Mitsuya, Hiroaki, Parniak, Michael A., Singh, Kamalendra, Sarafianos, Stefan G.
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2012
נושאים:
Nucleic Acid Enzymes
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245923/
https://ncbi.nlm.nih.gov/pubmed/21908397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr694
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