Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase

We report key mechanistic differences between the reverse transcriptases (RT) of human immunodeficiency virus type-1 (HIV-1) and of xenotropic murine leukemia virus-related virus (XMRV), a gammaretrovirus that can infect human cells. Steady and pre-steady state kinetics demonstrated that XMRV RT is...

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Main Authors: Ndongwe, Tanyaradzwa P., Adedeji, Adeyemi O., Michailidis, Eleftherios, Ong, Yee Tsuey, Hachiya, Atsuko, Marchand, Bruno, Ryan, Emily M., Rai, Devendra K., Kirby, Karen A., Whatley, Angela S., Burke, Donald H., Johnson, Marc, Ding, Shilei, Zheng, Yi-Min, Liu, Shan-Lu, Kodama, Ei-Ichi, Delviks-Frankenberry, Krista A., Pathak, Vinay K., Mitsuya, Hiroaki, Parniak, Michael A., Singh, Kamalendra, Sarafianos, Stefan G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2012
Ábhair:
Nucleic Acid Enzymes
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245923/
https://ncbi.nlm.nih.gov/pubmed/21908397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr694
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