Structural and Inhibition Studies of the RNase H Function of Xenotropic Murine Leukemia Virus-Related Virus Reverse Transcriptase

RNase H inhibitors (RNHIs) have gained attention as potential HIV-1 therapeutics. Although several RNHIs have been studied in the context of HIV-1 reverse transcriptase (RT) RNase H, there is no information on inhibitors that might affect the RNase H activity of other RTs. We performed biochemical,...

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Main Authors: Kirby, Karen A., Marchand, Bruno, Ong, Yee Tsuey, Ndongwe, Tanyaradzwa P., Hachiya, Atsuko, Michailidis, Eleftherios, Leslie, Maxwell D., Sietsema, Daniel V., Fetterly, Tracy L., Dorst, Christopher A., Singh, Kamalendra, Wang, Zhengqiang, Parniak, Michael A., Sarafianos, Stefan G.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2012
主題:
Antiviral Agents
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318313/
https://ncbi.nlm.nih.gov/pubmed/22252812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06000-11
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