RNA INTERFERENCE AGAINST CFTR AFFECTS HL60-DERIVED NEUTROPHIL MICROBICIDAL FUNCTION

Biosynthesis of hypochlorous acid (HOCl), a potent anti-microbial oxidant, in phagosomes is one of the chief mechanisms employed by polymorphonuclear neutrophils (PMNs) to combat infections. This reaction, catalyzed by myeloperoxidase, requires chloride anion (Cl(−)) as a substrate. Thus, Cl(−) avai...

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Bibliografiske detaljer
Main Authors: Bonvillain, Ryan W., Painter, Richard G., Adams, Daniel E., Viswanathan, Anand, Lanson, Nicholas A., Wang, Guoshun
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005861/
https://ncbi.nlm.nih.gov/pubmed/20870018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2010.09.012
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