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RNA INTERFERENCE AGAINST CFTR AFFECTS HL60-DERIVED NEUTROPHIL MICROBICIDAL FUNCTION
Biosynthesis of hypochlorous acid (HOCl), a potent anti-microbial oxidant, in phagosomes is one of the chief mechanisms employed by polymorphonuclear neutrophils (PMNs) to combat infections. This reaction, catalyzed by myeloperoxidase, requires chloride anion (Cl(−)) as a substrate. Thus, Cl(−) avai...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3005861/ https://ncbi.nlm.nih.gov/pubmed/20870018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2010.09.012 |
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