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Activation of the NLRP3 inflammasome by intracellular poly I:C
Several RNA viruses can be detected by the inflammasome, which promotes IL-1β and IL-18 secretion, but the underlying mechanisms of detection remain unclear. Cytosolic dsRNA is a replication intermediate of many RNA viruses. We show here that transfection of the dsRNA analogue poly I:C activates the...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3005299/ https://ncbi.nlm.nih.gov/pubmed/20971108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2010.10.036 |
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