Llwytho...

Activation of the NLRP3 inflammasome by intracellular poly I:C

Several RNA viruses can be detected by the inflammasome, which promotes IL-1β and IL-18 secretion, but the underlying mechanisms of detection remain unclear. Cytosolic dsRNA is a replication intermediate of many RNA viruses. We show here that transfection of the dsRNA analogue poly I:C activates the...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Rajan, Jayant V., Warren, Sarah E., Miao, Edward A., Aderem, Alan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005299/
https://ncbi.nlm.nih.gov/pubmed/20971108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2010.10.036
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