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IFNβ therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome

Interferon-β (IFN-β) is widely used to treat multiple sclerosis (MS), and its efficacy was demonstrated in the setting of experimental autoimmune encephalomyelitis (EAE), an animal model of MS; however, IFN-β is not effective in treating all cases of MS. Here, we demonstrate that signaling by IFNAR...

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Bibliografski detalji
Glavni autori: Inoue, Makoto, Williams, Kristi L., Oliver, Timothy, Vandenabeele, Peter, Rajan, Jayant V., Miao, Edward A., Shinohara, Mari L.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3509177/
https://ncbi.nlm.nih.gov/pubmed/22623753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2002767
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