Aromatase Is a Direct Target of FOXL2: C134W in Granulosa Cell Tumors via a Single Highly Conserved Binding Site in the Ovarian Specific Promoter

BACKGROUND: Granulosa cell tumors (GCT) of the ovary often express aromatase and synthesize estrogen, which in turn may influence their progression. Recently a specific point mutation (C134W) in the FOXL2 protein was identified in >94% of adult-type GCT and it is likely to contribute to their dev...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Fleming, Nicholas I., Knower, Kevin C., Lazarus, Kyren A., Fuller, Peter J., Simpson, Evan R., Clyne, Colin D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2010
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3004790/
https://ncbi.nlm.nih.gov/pubmed/21188138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0014389
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi