Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target

Granulosa cell tumors (GCT) are rare ovarian malignancies. Due to the lack of effective treatment in late relapse, there is a clear unmet need for novel therapies. Forkhead Box L2 (FOXL2) is a protein mainly expressed in granulosa cells (GC) and therefore is a rational therapeutic target. Since we i...

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Publicado no:JCI Insight
Main Authors: Pierini, Stefano, Tanyi, Janos L., Simpkins, Fiona, George, Erin, Uribe-Herranz, Mireia, Drapkin, Ronny, Burger, Robert, Morgan, Mark A., Facciabene, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7455139/
https://ncbi.nlm.nih.gov/pubmed/32814714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136773
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