Gut microbiota modulates adoptive cell therapy via CD8α dendritic cells and IL-12

Adoptive T cell therapy (ACT) is a promising new modality for malignancies. Here, we report that adoptive T cell efficacy in tumor-bearing mice is significantly affected by differences in the native composition of the gut microbiome or treatment with antibiotics, or by heterologous fecal transfer. D...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Uribe-Herranz, Mireia, Bittinger, Kyle, Rafail, Stavros, Guedan, Sonia, Pierini, Stefano, Tanes, Ceylan, Ganetsky, Alex, Morgan, Mark A., Gill, Saar, Tanyi, Janos L., Bushman, Frederic D., June, Carl H., Facciabene, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916241/
https://ncbi.nlm.nih.gov/pubmed/29467322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.94952
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