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Aromatase expression is increased in BRCA1 mutation carriers

BACKGROUND: Until recently, the molecular mechanisms explaining increased incidence of ovarian and breast cancers in carriers of BRCA1 gene mutations had not been clearly understood. Of significance is the finding that BRCA1 negatively regulates aromatase expression in vitro. Our objective was to ch...

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Hlavní autoři: Chand, Ashwini L, Simpson, Evan R, Clyne, Colin D
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2689243/
https://ncbi.nlm.nih.gov/pubmed/19445691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-9-148
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