Mutant FOXL2(C134W) highjacks SMAD4 and SMAD2/3 to drive adult granulosa cell tumors

The mutant protein FOXL2(C134W) is expressed in at least 95% of adult-type ovarian granulosa cell tumors (AGCT) and is considered to be a driver of oncogenesis in this disease. However, the molecular mechanism by which FOXL2(C134W) contributes to tumorigenesis is not known. Here we show that mutant...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Weis-Banke, Stine E., Lerdrup, Mads, Kleine-Kohlbrecher, Daniela, Mohammad, Faizaan, Sidoli, Simone, Jensen, Ole N., Yanase, Toshihiko, Nakamura, Tomoko, Iwase, Akira, Stylianou, Anthe, Abu-Rustum, Nadeem R., Aghajanian, Carol, Soslow, Robert, Paula, Arnaud Da Cruz, Koche, Richard P., Weigelt, Britta, Christensen, Jesper, Helin, Kristian, Cloos, Paul A.C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8278322/
https://ncbi.nlm.nih.gov/pubmed/32641411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-0259
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