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Granulosa cell tumor mutant FOXL2(C134W) suppresses GDF-9 and activin A-induced follistatin transcription in primary granulosa cells
A single somatic FOXL2 mutation (FOXL2(C134W)) was identified in almost all granulosa cell tumor (GCT) patients. In the pituitary, FOXL2 and Smad3 coordinately regulate activin stimulation of follistatin transcription. We explored whether a similar regulation occurs in the ovary, and whether FOXL2(C...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3669547/ https://ncbi.nlm.nih.gov/pubmed/23567549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2013.03.021 |
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