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The human cytoplasmic RNA terminal U-transferase ZCCHC11 targets histone mRNAs for degradation

Inhibition of eukaryotic DNA replication leads to the rapid suppression of histone synthesis, via 3′ uridylation of cytoplasmic histone mRNAs followed by their Lsm1–7-mediated decapping and degradation. Here we show that the human cytoplasmic RNA terminal U-transferase ZCCHC11, recently implicated i...

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Autori principali: Schmidt, Marie-Joëlle, West, Steven, Norbury, Chris J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3004064/
https://ncbi.nlm.nih.gov/pubmed/21051505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2252511
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