Initial Testing of a Monoclonal Antibody (IMC-A12) against IGF-1R by the Pediatric Preclinical Testing Program

BACKGROUND: Many childhood malignancies including sarcomas, neuroblastoma and Wilms tumor show the presence of both, active, type-1-insulin-like growth factor receptor (IGF-1R), and the autocrine production of its ligands IGF-1/IGF-2. IMC-A12 is a fully human IgG1 antibody that prevents ligand bindi...

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Main Authors: Houghton, Peter J., Morton, Christopher L., Gorlick, Richard, Kolb, E. Anders, Keir, Stephen T., Reynolds, C. Patrick, Kang, Min H., Maris, John M., Wu, Jianrong, Smith, Malcolm A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003867/
https://ncbi.nlm.nih.gov/pubmed/20166202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.22367
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