Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

TET2 is a close relative of TET1, an enzyme that converts 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) in DNA1,2. The gene encoding TET2 resides at chromosome 4q24, in a region showing recurrent microdeletions and copy-neutral loss of heterozygosity (CN-LOH) in patients with diverse my...

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Hauptverfasser: Ko, Myunggon, Huang, Yun, Jankowska, Anna M., Pape, Utz J., Tahiliani, Mamta, Bandukwala, Hozefa S., An, Jungeun, Lamperti, Edward D., Koh, Kian Peng, Ganetzky, Rebecca, Liu, X. Shirley, Aravind, L., Agarwal, Suneet, Maciejewski, Jaroslaw P., Rao, Anjana
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003755/
https://ncbi.nlm.nih.gov/pubmed/21057493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09586
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