Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

The Ten-Eleven-Translocation 2 (TET2) gene encodes a member of TET family enzymes that alters the epigenetic status of DNA by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine (5hmC). Somatic loss-of-function mutations of TET2 are frequently observed in patients with diverse myeloid malignancies...

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Bibliographic Details
Main Authors: Ko, Myunggon, Bandukwala, Hozefa S., An, Jungeun, Lamperti, Edward D., Thompson, Elizabeth C., Hastie, Ryan, Tsangaratou, Angeliki, Rajewsky, Klaus, Koralov, Sergei B., Rao, Anjana
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3167529/
https://ncbi.nlm.nih.gov/pubmed/21873190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112317108
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