Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX

TET (Ten-Eleven-Translocation) proteins are Fe(II) and α-ketoglutarate-dependent dioxygenases(1-3) that modify the methylation status of DNA by successively oxidizing 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine and 5-carboxycytosine(1,3-5), potential intermediates in t...

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Detalhes bibliográficos
Main Authors: Ko, Myunggon, An, Jungeun, Bandukwala, Hozefa S., Chavez, Lukas, Äijö, Tarmo, Pastor, William A., Segal, Matthew F., Li, Huiming, Koh, Kian Peng, Lähdesmäki, Harri, Hogan, Patrick G., Aravind, L., Rao, Anjana
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643997/
https://ncbi.nlm.nih.gov/pubmed/23563267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12052
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