KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents

Fanconi anemia (FA) is a rare genetic disease characterized by congenital defects, bone marrow failure, chromosomal instability, and cancer susceptibility. One hallmark of cells from FA patients is hypersensitivity to interstrand cross-linking agents, such as the chemotherapeutics cisplatin and mito...

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Detalhes bibliográficos
Main Authors: Yoshikiyo, Kazunori, Kratz, Katja, Hirota, Kouji, Nishihara, Kana, Takata, Minoru, Kurumizaka, Hitoshi, Horimoto, Satoshi, Takeda, Shunichi, Jiricny, Josef
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003052/
https://ncbi.nlm.nih.gov/pubmed/21115814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1011081107
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