Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2

DNA interstrand crosslinks (ICLs) are highly toxic because they block the progression of replisomes. The Fanconi Anemia (FA) proteins, encoded by genes that are mutated in FA, are important for repair of ICLs. The FA core complex catalyzes the monoubiquitination of FANCD2, and this event is essentia...

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Detalhes bibliográficos
Main Authors: MacKay, Craig, Déclais, Anne-Cécile, Lundin, Cecilia, Agostinho, Ana, Deans, Andrew J., MacArtney, Thomas J., Hofmann, Kay, Gartner, Anton, West, Stephen C., Helleday, Thomas, Lilley, David M.J., Rouse, John
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710700/
https://ncbi.nlm.nih.gov/pubmed/20603015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.06.021
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