Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2

DNA interstrand crosslinks (ICLs) are highly toxic because they block the progression of replisomes. The Fanconi Anemia (FA) proteins, encoded by genes that are mutated in FA, are important for repair of ICLs. The FA core complex catalyzes the monoubiquitination of FANCD2, and this event is essentia...

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Hlavní autoři: MacKay, Craig, Déclais, Anne-Cécile, Lundin, Cecilia, Agostinho, Ana, Deans, Andrew J., MacArtney, Thomas J., Hofmann, Kay, Gartner, Anton, West, Stephen C., Helleday, Thomas, Lilley, David M.J., Rouse, John
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710700/
https://ncbi.nlm.nih.gov/pubmed/20603015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.06.021
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