Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway

Interstrand cross-links (ICLs) block replication and transcription and thus are highly cytotoxic. In higher eukaryotes, ICLs processing involves the Fanconi anemia (FA) pathway and homologous recombination. Stalled replication forks activate the eight-subunit FA core complex, which ubiquitylates FAN...

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Bibliografiske detaljer
Main Authors: Yamamoto, Kimiyo N., Kobayashi, Shunsuke, Tsuda, Masataka, Kurumizaka, Hitoshi, Takata, Minoru, Kono, Koichi, Jiricny, Josef, Takeda, Shunichi, Hirota, Kouji
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3080998/
https://ncbi.nlm.nih.gov/pubmed/21464321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1018487108
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