Expression, regulation and function of phosphofructo-kinase/fructose-biphosphatases (PFKFBs) in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia cells

BACKGROUND: Glucocorticoids (GCs) cause apoptosis and cell cycle arrest in lymphoid cells and constitute a central component in the therapy of lymphoid malignancies, most notably childhood acute lymphoblastic leukemia (ALL). PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-2), a kinase co...

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Autors principals: Carlet, Michela, Janjetovic, Kristina, Rainer, Johannes, Schmidt, Stefan, Panzer-Grümayer, Renate, Mann, Georg, Prelog, Martina, Meister, Bernhard, Ploner, Christian, Kofler, Reinhard
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3002928/
https://ncbi.nlm.nih.gov/pubmed/21092265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-638
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