6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase-2 regulates TP53-dependent paclitaxel sensitivity in ovarian and breast cancers

PURPOSE: Paclitaxel is an integral component of primary therapy for breast and epithelial ovarian cancers, but less than half of these cancers respond to the drug. Enhancing the response to primary therapy with paclitaxel could improve outcomes for women with both diseases. EXPERIMENTAL DESIGN: Twel...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Yang, Hailing, Zhang, Shu, Jiang, Yongying, Mao, Weiqun, Pang, Lan, Redwood, Abena, Jeter-Jones, Sabrina, Jennings, Nicholas, Ornelas, Argentina, Zhou, Jinhua, Rodriguez-Aguayo, Cristian, Bartholomeusz, Geoffrey, Iles, LaKesla R., Zacharias, Niki M., Millward, Steven W., Lopez-Berestein, Gabriel, Le, Xiao-Feng, Ahmed, Ahmed A., Piwnica-Worms, Helen, Sood, Anil K., Bast, Robert C., Lu, Zhen
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744996/
https://ncbi.nlm.nih.gov/pubmed/31391192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-3448
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