The synthetic glucocorticoids prednisolone and dexamethasone regulate the same genes in acute lymphoblastic leukemia cells

BACKGROUND: Glucocorticoids (GCs) cause apoptosis in malignant cells of lymphoid lineage by transcriptionally regulating a plethora of genes. As a result, GCs are included in almost all treatment protocols for lymphoid malignancies, particularly childhood acute lymphoblastic leukemia (chALL). The mo...

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Hlavní autoři: Bindreither, Daniel, Ecker, Simone, Gschirr, Barbara, Kofler, Anita, Kofler, Reinhard, Rainer, Johannes
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133055/
https://ncbi.nlm.nih.gov/pubmed/25103118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-662
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