Profiling Diverse Compounds by Flux- and Electrophysiology-Based Primary Screens for Inhibition of Human Ether-à-go-go Related Gene Potassium Channels

Compound effects on cloned human Ether-à-go-go related gene (hERG) potassium channels have been used to assess the potential cardiac safety liabilities of drug development candidate compounds. In addition to radioactive ligand displacement tests, two other common approaches are surrogate ion-based f...

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Detalhes bibliográficos
Main Authors: Zou, Beiyan, Yu, Haibo, Babcock, Joseph J., Chanda, Pritam, Bader, Joel S., McManus, Owen B., Li, Min
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2010
Assuntos:
Ion Channels and Transporters Focus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3002177/
https://ncbi.nlm.nih.gov/pubmed/21158688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2010.0339
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